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  • Title: Activation of lamina propria T lymphocytes in Crohn's disease.
    Author: Qiao L, Schürmann G, Meuer SC, Autschbach F.
    Journal: Adv Exp Med Biol; 1995; 371B():1287-91. PubMed ID: 7502802.
    Abstract:
    Crohn's disease is characterized by chronic inflammatory infiltrates and granuloma formation in the gut. T cell directed immunotherapy appears to be effective in relieving these symptoms. Under normal conditions, lamina propria T lymphocytes have a low proliferative response to antigen receptor stimulation in vitro due to the influence of the local intestinal environment. This study shows that lamina propria T lymphocytes exhibit an enhanced response to antigen receptor stimulation in active Crohn's disease, which may contribute in its pathogenesis.
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