These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Calcium antagonists and prevention of post-angioplasty restenosis].
    Author: Hoberg E.
    Journal: Arch Mal Coeur Vaiss; 1995 Sep; 88 Spec No 4():29-34. PubMed ID: 7503622.
    Abstract:
    Five randomised double blind clinical trials have assessed the effects of long term therapy with calcium antagonists on post-coronary angioplasty restenosis. Nifedipine 40 mg/day was tested in 241 patients by Whitworth et al: there was no difference in the incidence of restenosis between the treatment and placebo groups. Corcos et al studied the effects of diltiazem 270 mg/day in 92 patients: there was no significant difference between the two groups. In a study of 201 patients, O'Keefe et al found no significant difference in incidence of restenosis in a group treated with diltiazem (240 to 360 mg/day) compared with placebo. The fourth trial, conducted by Unverdorben et al, not yet fully published, in 170 patients, showed a significant reduction in restenosis in patients treated with diltiazem 180 mg/day (p = 0.03). Finally, the VAS trial (Verapamil Angioplasty Study) showed high dose verapamil (480 mg/day) to reduce the incidence of restenosis in a subgroup of patients with stable angina and high risk of restenosis.
    [Abstract] [Full Text] [Related] [New Search]