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  • Title: Prostacyclin contributes to nitroglycerin-mediated relaxation of human umbilical arteries.
    Author: Klockenbusch W, Schrör K.
    Journal: J Cardiovasc Pharmacol; 1993 Sep; 22(3):510-1. PubMed ID: 7504146.
    Abstract:
    This study compared the action of nitroglycerin (GTN) and linsidomine (SIN-1) on vessel tone and prostacyclin (PGI2) production of human umbilical arteries in vitro. GTN-induced vessel relaxation was significantly attenuated by indomethacin pretreatment. This was associated with a significant inhibition of the fourfold stimulation of PGI2 release by GTN. No such effects were seen with SIN-1. We concluded that GTN-induced PGI2 release contributed to the vasodilatory action of organic nitrates in the fetoplacental circulation.
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