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  • Title: Activation of exocytosis by the heterotrimeric G protein Gi3.
    Author: Aridor M, Rajmilevich G, Beaven MA, Sagi-Eisenberg R.
    Journal: Science; 1993 Dec 03; 262(5139):1569-72. PubMed ID: 7504324.
    Abstract:
    Secretagogues of rat peritoneal mast cells, such as mastoparan and compound 48/80, induce mast cell exocytosis by activating directly the guanosine triphosphate-binding proteins that are required for exocytosis. The introduction of a synthetic peptide that corresponds to the carboxyl-terminal end sequence of G alpha i3 into the cells specifically blocked this secretion. Similar results were obtained when antibodies to this peptide were introduced. The G alpha i3 was located in both the Golgi and the plasma membrane, but only the latter source of G alpha i3 appeared to be essential for secretion. These results indicate that G alpha i3 functions to control regulated exocytosis in mast cells.
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