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  • Title: [Analysis of ovalbumin-specific T cell lines established from patients with hen egg allergy].
    Author: Katsuki T, Shimojo N, Honma K, Kohno Y, Niimi H, Coligan JE, Tsunoo H.
    Journal: Arerugi; 1993 Oct; 42(10):1610-5. PubMed ID: 7504444.
    Abstract:
    Ten ovalbumin (OVA)-specific T cell lines (TCLs) were established from peripheral blood mononuclear cells of 6 patients with hen egg allergy, and the antigen recognition of these TCLs was characterized. Two OVA epitopes were determined by use of 3 synthetic OVA peptides which have been known as murine T cell epitopes. Blocking of antigen-specific T cell proliferation by anti-HLA class II monoclonal antibodies suggest that all 3 HLA class II molecules could act as restriction elements for T cell recognition of OVA. This is the first demonstration of OVA epitopes recognized by T cells in patients with hen egg allergy, as far as we know.
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