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  • Title: Modulation by fatty acids of Ca2+ fluxes in sarcoplasmic-reticulum vesicles.
    Author: Cardoso CM, De Meis L.
    Journal: Biochem J; 1993 Nov 15; 296 ( Pt 1)(Pt 1):49-52. PubMed ID: 7504458.
    Abstract:
    The fatty acids palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and arachidonic (C20:4) acids inhibit Ca2+ uptake and enhance Ca2+ efflux measured in vesicles derived from the sarcoplasmic reticulum of skeletal muscle. These effects of the fatty acids are impaired by the Ca(2+)-ATPase ligands Mg2+, Ca2+ and K+, and by drugs that block the leakage of Ca2+ through the Ca(2+)-ATPase such as Ruthenium Red, spermine [de Meis (1991) J. Biol. Chem. 266, 5736-5742] and thapsigargin [de Meis and Inesi (1992) FEBS Lett. 299, 33-35].
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