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  • Title: Expression of human endogenous retrovirus (HERV-K) in chronic myeloid leukemia.
    Author: Brodsky I, Foley B, Gillespie D.
    Journal: Leuk Lymphoma; 1993; 11 Suppl 1():119-23. PubMed ID: 7504541.
    Abstract:
    We have previously demonstrated the presence of a reverse transcriptase-like enzyme in retroviral particles from patients with essential thrombocythemia, polycythemia vera, and chronic myelogenous leukemia. It was subsequently shown that the human genome contains 50 copies of HERV-K. HERV-K is a human endogenous class I retroviral element that contains gag, pol, and env open reading frames. Using both reverse transcriptase-polymerase chain reaction and ribonuclease protection assays, it is demonstrated that the HERV-K pol is expressed in human blood leukocytes. The data indicates that this expression is restricted in CML white cells and is the result of gene regulation.
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