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  • Title: Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.
    Author: Jumper MD, Splawski JB, Lipsky PE, Meek K.
    Journal: J Immunol; 1994 Jan 15; 152(2):438-45. PubMed ID: 7506723.
    Abstract:
    Stimulation of human B cells with mAb to CD40 in the presence of IL-4 induces proliferation and differentiation into Ig-secreting cells. To delineate the molecular events leading to Ig secretion after stimulation via the CD40 molecule, the induction of germ-line transcripts of Ig H chain isotypes was analyzed by polymerase chain reaction. The results document that costimulation with mAb to CD40 and IL-4 induces sterile transcription of all Ig H chain isotypes. Of importance, stimulation with mAb to CD40 without the addition of IL-4 induced germ-line transcription of most downstream isotypes, suggesting that this signal is sufficient to initiate the first step in switch recombination.
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