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  • Title: Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck.
    Author: Vignali DA, Doyle C, Kinch MS, Shin J, Strominger JL.
    Journal: Philos Trans R Soc Lond B Biol Sci; 1993 Oct 29; 342(1299):13-24. PubMed ID: 7506833.
    Abstract:
    CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.
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