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  • Title: Insulin induces tyrosine phosphorylation of a 90-kDa protein during postischemic brain reperfusion.
    Author: DeGracia DJ, O'Neil BJ, White BC, Tiffany BR, Krause GS, Grossman LI, Grunberger G.
    Journal: Exp Neurol; 1993 Dec; 124(2):351-6. PubMed ID: 7507063.
    Abstract:
    Rat brain nuclear proteins were examined for tyrosine phosphorylation after resuscitation from a 10-min cardiac arrest. Insulin (1 unit/kg intravenously), given immediately after resuscitation, caused a marked increase in tyrosine phosphorylation of a 90-kDa brain protein. This effect occurred without hypoglycemia and was not observed after insulin administration in previously insulinopenic, diabetic, nonischemic animals. Insulin-responsive tyrosine phosphorylation of a specific 90-kDa protein during reperfusion may represent insulin stimulation of a neuroprotective brain response to an ischemic insult, consistent with recent observations that insulin administration during reperfusion protects selectively vulnerable neurons from postischemic death.
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