These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antiplatelet granule membrane protein (GMP-140) autoantibodies detected in plasma from patients with idiopathic thrombocytopenic purpura.
    Author: Jiang H, Wu G, Zhang W, Zhao Y, Xi X, Ruan C.
    Journal: Nouv Rev Fr Hematol (1978); 1993; 35(5):487-90. PubMed ID: 7507587.
    Abstract:
    Plasma from 92 patients with idiopathic thrombocytopenic purpura (ITP) was tested for autoantibodies against granule membrane protein 140 (GMP-140) using an antigen specific immunoassay. Results showed that autoantibodies to GMP-140 existed in 17 of these patients (18.5%). Incubation of patient plasma with purified GMP-140, immobilized on nitrocellulose strips by SDS-PAGE and Western blotting, revealed a staining band at the level of GMP-140 in two of 8 plasmas. Autoantibodies to GMP-140 often coexisted with other autoantibodies, in particular towards GP Ib/IX (3 cases), GP IIb-IIIa (5 cases) or both (3 cases). This study provides direct evidence for the presence of anti-platelet GMP-140 autoantibodies in some patients with ITP.
    [Abstract] [Full Text] [Related] [New Search]