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  • Title: Heterosexual transmission of human immunodeficiency virus type 1 variants associated with zidovudine resistance.
    Author: Conlon CP, Klenerman P, Edwards A, Larder BA, Phillips RE.
    Journal: J Infect Dis; 1994 Feb; 169(2):411-5. PubMed ID: 7508970.
    Abstract:
    During zidovudine therapy, human immunodeficiency virus type 1 (HIV-1) acquires a distinctive set of mutations that diminish the sensitivity of the virus to this drug in vitro. An AIDS patient is described who, while being treated with zidovudine, transmitted HIV-1 bearing a drug resistance mutation to a young woman who had never received zidovudine treatment. DNA sequencing of HIV-1 proviruses confirmed that these 2 persons shared HIV genetic variants, including a mutation at codon 70 in the reverse transcriptase gene associated with reduced in vitro sensitivity to zidovudine. This mutation persisted in the woman > 1 year in the absence of antiretroviral therapy. HIV-1 with genetic markers of zidovudine resistance can be transmitted heterosexually, but it is uncertain whether dissemination of drug-resistant virus will substantially reduce the usefulness of this drug.
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