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  • Title: Potentiating effect of Bay K 8644 on agonist-induced ileal contractions.
    Author: Gacar NM, Kalyoncu NI, Aksoy Z, Sivrikaya N, Ugurbas O, Mollaoglu AH, Caglar M.
    Journal: Pol J Pharmacol; 1993; 45(4):413-9. PubMed ID: 7509687.
    Abstract:
    The effects of Bay K 8644 on agonist-induced ileal contractions were investigated. Histamine, serotonin and a acetylcholine (10(-8)-10(-4) M) produced a dose-dependent contraction. Maximum contraction was obtained by 10(-5) M serotonin. Its value was 1076 mg. Bay K 8644 (10(-6) M) increased the potency of histamine and serotonin-induced ileal contractions, but acetylcholine induced responses were not increased. All responses of agonists were inhibited by nifedipine (10(-6) M). This inhibition was decreased with increasing acetylcholine concentrations. These results suggest that histamine and serotonin induced/mediated contractions in guinea-pig ileum are independent of calcium influx through voltage operated channels.
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