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  • Title: Genotoxic activity of mebendazole in Aspergillus nidulans.
    Author: de la Torre RA, Espinosa-Aguirre JJ, Cortinas de Nava C, Izquierdo T, Moron F.
    Journal: Mutat Res; 1994 Mar 01; 305(2):139-44. PubMed ID: 7510023.
    Abstract:
    Mebendazole is an anthelmintic drug widely used in Cuba and in Mexico. Its interaction with tubulin interferes with the assemblage of the mitotic apparatus in the parasite cells, thus suggesting a possible genotoxic activity leading to chromosomal malsegregation. The heterozygous diploid strain D30 of Aspergillus nidulans was used to establish the ability of mebendazole to induce mitotic recombination and/or chromosomal non-disjunction, and the haploid strain FGSC #219 of A. nidulans was used to study the ability of mebendazole to induce point mutations in the methG suppressor system. Our results show that mebendazole can induce chromosomal non-disjunction but it fails to promote point mutations.
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