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  • Title: [Significance of AgNOR analysis of urothelial carcinomas].
    Author: Helpap B, Loesevitz L.
    Journal: Verh Dtsch Ges Pathol; 1993; 77():222-5. PubMed ID: 7511285.
    Abstract:
    Biopsies of normal and atypical/dysplastic epithelium of the urinary bladder as well as transitional cell carcinomas grades I to III were stained with a silver nitrate solution, and the silver-stained nucleolar organizer regions were evaluated. The AgNOR-analysis shows highly significant differences in the G II subgroups, similar to the results of nucleolar subgrading. Because of the significantly differing 5-year survival rates, it can be justified to divide transitional cell carcinomas into two groups: a low-risk group with favorable prognosis (G Ia to G IIa), and a high-risk group with poor prognosis (G IIb to G IIIa,b).
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