These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hydralazine dilates large epicardial coronary arteries in conscious dogs through an endothelium-independent mechanism.
    Author: Drieu la Rochelle C, Dubois-Randé JL, Hittinger L, Richard V, Berdeaux A, Giudicelli JF.
    Journal: J Cardiovasc Pharmacol; 1994 Feb; 23(2):315-8. PubMed ID: 7511763.
    Abstract:
    In chronically instrumented conscious dogs, hydralazine (30-300 micrograms/kg) and nitroglycerin (NTG 0.03-10 micrograms/kg) dose-dependently dilated large epicardial coronary arteries. Simultaneously, hydralazine also dose-dependently dilated small coronary arteries, whereas a similar effect was observed only after NTG > 0.3 microgram/kg. When large coronary arteries were deendothelialized by a balloon angioplasty catheter, dilation of large coronary arteries in response to acetylcholine (ACh 0.3 microgram/kg) and to reactive hyperemia was reduced by 87 and 95%, respectively. In contrast, vasodilation of large coronary arteries induced by hydralazine and NTG was only minimally and similarly affected (-19% for both drugs). These findings demonstrate that in vivo hydralazine-induced dilation of large coronary arteries is endothelium independent.
    [Abstract] [Full Text] [Related] [New Search]