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  • Title: Corticotropin-releasing factor stimulates Ca2+ influx in cultured rat astrocytes.
    Author: Takuma K, Matsuda T, Yoshikawa T, Kitanaka J, Gotoh M, Hayata K, Baba A.
    Journal: Biochem Biophys Res Commun; 1994 Mar 30; 199(3):1103-7. PubMed ID: 7511890.
    Abstract:
    Corticotropin-releasing factor (CRF) increased intracellular Ca2+ concentration in single astrocytes. The effect in increasing intracellular Ca2+ was not observed in Ca2(+)-free solution. Furthermore, CRF at concentrations more than 10 nM stimulated 45Ca2+ uptake in cultured rat astrocytes. The action was blocked by alpha-helical CRF(9-41) in a competitive manner, but not by nifedipine and 3,4-dichlorobenzamil. On the other hand, CRF did not stimulate cAMP formation, cGMP formation and phosphoinositide hydrolysis in astrocytes. These results indicate that CRF increases Ca2+ influx via an activation of CRF receptors in a cAMP-independent mechanism in cultured astrocytes.
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