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  • Title: [Status of nucleic acid and total protein synthesis in hematopoietic organs in mice with alloxan diabetes].
    Author: Kozlov IuA, Volkova NP, Baĭkov AN, Novitskiĭ VV.
    Journal: Vopr Med Khim; 1994; 40(2):19-21. PubMed ID: 7512777.
    Abstract:
    Rates of 3H-thymidine, 3H-uridine and 14C-glycine incorporation in nucleic acids and total proteins were studied in cells of bone marrow, spleen, thymus and ileocecal lymph nodes tissues of BALB/c mice with subacute alloxan diabetes (content of blood sugar was higher than 14 mmol/l). Synthesis of DNA, RNA and protein was not considerably inhibited in the thymus tissue of the impaired animals which may correlate with pronounced dysfunction of cytotoxic T lymphocytes typical for the disease.
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