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  • Title: Clinical and biologic characteristics of CD7+ acute myeloid leukemia. Our experience and literature review.
    Author: Shimamoto T, Ohyashiki JH, Ohyashiki K, Kawakubo K, Inatomi Y, Fujieda H, Nakazawa S, Kimura N, Miyauchi J, Toyama K.
    Journal: Cancer Genet Cytogenet; 1994 Mar; 73(1):69-74. PubMed ID: 7513604.
    Abstract:
    Six patients with acute myeloid leukemia (AML) expressing CD7 antigen (CD7+ AML) were studied. They consisted of five patients with M1 and one with an M2 morphology. Two cases expressed other lymphoid-associated antigens, in addition to CD7. The complete remission rate was 50%. One patient had central nervous system recurrence. Cytogenetic analysis demonstrated normal karyotypes in all the cases. All but one had germline configurations of the T-cell receptor (TCR) genes and immunoglobulin heavy chain gene. However, all did not have detectable recombinase activating gene-1 activity by the RT-PCR technique. We performed colony formation assay in two patients, and no enhancement of colony formation by granulocyte colony-stimulating factor was noted. The results presented here, together with those reported previously, suggest that CD7+ AML may demonstrate lineage infidelity.
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