These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthetic peptides in the determination of hepatitis A virus T-cell epitopes.
    Author: Ivanov VS, Kulik LN, Gabrielian AE, Tchikin LD, Kozhich AT, Ivanov VT.
    Journal: FEBS Lett; 1994 May 30; 345(2-3):159-61. PubMed ID: 7515358.
    Abstract:
    Computer search for probable T-epitopes of hepatitis A virus capsid proteins was performed using an integrated set of programs. Eight segments of the VP1, VP2, VP3 and VP4 proteins were chosen and synthesised. Five peptides previously examined as probable B-epitopes were used as well. All the peptides were tested for their ability to stimulate proliferation of lymph node T-cells primed with synthetic peptides. Almost all predicted T-epitopes affected the T-cell proliferation. None of the peptides had mitogenic activity. We demonstrated that regions 17-33 and 276-298 of VP1 are possible immunodominant promiscuous sites activating lymphocytes of all mouse haplotypes.
    [Abstract] [Full Text] [Related] [New Search]