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  • Title: Neurogenic "off" contractions are mediated by NK2-receptors in the circular muscle of guinea pig ileum.
    Author: Suzuki N, Mizuno K, Gomi Y.
    Journal: Jpn J Pharmacol; 1994 Mar; 64(3):213-6. PubMed ID: 7517466.
    Abstract:
    In guinea pig ileal circular muscle, electrical stimulations by a train of 10-100 pulses (0.05-msec duration, 10 Hz) produced tetrodotoxin-sensitive "off" contractions that were initiated upon the termination of stimulations. Atropine at 10(-6) M did not inhibit the "off" contractions. FK224 at 10(-5) M, a dual antagonist for NK1- and NK2-receptors, but not 10(-7) M CP-96,345, an antagonist for NK1-receptors, almost abolished the "off" contractions in the presence of atropine. These results suggest that the neurogenic "off" contraction was mediated mainly by NK2-receptors in the circular muscle of guinea pig ileum.
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