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  • Title: In vitro induction of uncoiled chromosomes with inhibitors of RNA and protein synthesis.
    Author: Rønne M, Andersen O.
    Journal: Cytobios; 1978; 21(81):7-21. PubMed ID: 751778.
    Abstract:
    When inhibitors of cellular DNA, RNA or protein synthesis are added to the growth medium of human lymphoid cells in G2 phase, these agents produce, within narrow ranges of concentrations, G banded or uncoiled chromosomes in the treated metaphase cells. It is suggested that the induced structural alteration is a consequence of an inhibition of the normal chromosome condensation and fusion of bands taking place between prometaphase and metaphase. This inhibition seems to be due to a partial inhibition of G2 phase synthesis of RNA and protein molecules, necessary for normal chromosome condensation in metaphase. It is found that this condensation can be reversed during a resting period after metaphase.
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