These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Discrimination between two subsets of porcine CD8+ cytolytic T lymphocytes by the expression of CD5 antigen.
    Author: Saalmüller A, Hirt W, Maurer S, Weiland E.
    Journal: Immunology; 1994 Apr; 81(4):578-83. PubMed ID: 7518796.
    Abstract:
    Previous work has revealed striking differences in the peripheral T-lymphocyte compartments of swine compared to other species. The key difference is the existence of four T-lymphocyte subpopulations defined by their CD4/CD8 expression. Besides this difference in the CD4/CD8 antigen expression, we report here another unusual antigen distribution on porcine extrathymic T lymphocytes: the expression of the 63,000 MW CD5 antigen. In porcine thymus the CD5 antigen shows a biphasic antigen density, whereas the majority of thymocytes are characterized by an intermediate CD5 expression. In the extrathymic T-lymphocyte compartment, CD5 also shows a heterogeneous antigen distribution as defined by three subsets: CD5high, CD5dim and CD5- T lymphocytes. Analyses of the CD5 expression on the four CD4/CD8-defined peripheral T-cell subpopulations revealed that all CD4+ T lymphocytes, CD4+ CD8+ as well as CD4+ CD8- T lymphocytes, belonged to the subset with high CD5 antigen density. The CD4- CD8- subpopulation, containing in the majority T-cell receptor (TcR) gamma delta T lymphocytes, was characterized by dim CD5 expression. The most notable difference was the division of the CD4- CD8+ cytolytic T-lymphocyte subpopulation into two CD5-defined subsets: CD4- CD5- CD8+ lymphocytes with spontaneous cytolytic activity against tumour cells, and CD4- CD5+ CD8+ T lymphocytes with major histocompatibility complex (MHC)-restricted cytolytic function. Thus, the porcine CD5 antigen is an important marker to discriminate between CD5- CD8+ natural killer (NK) cells and CD5+ CD8+ progenitors of MHC-restricted cytolytic T lymphocytes.
    [Abstract] [Full Text] [Related] [New Search]