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  • Title: Changes in liver drug glucuronidation during cholestasis are non predictable.
    Author: Ouvina GB, Lemberg A, Bengochea LA.
    Journal: Arch Int Physiol Biochim Biophys; 1994; 102(2):121-3. PubMed ID: 7519458.
    Abstract:
    Liver microsomal glucuronidation of acetaminophen, chloramphenicol, salicylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats showed a decrease of 31% for p-nitrophenol glucuronidation; salicylic acid glucuronidation increased 281%; acetaminophen glucuronidation increased 38% while morphine, chloramphenicol and lorazepam values were similar to controls. We concluded that cholestasis produces non predictable changes on liver drug glucuronidation pathways.
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