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  • Title: Increase by NO synthase inhibitors of acetylcholine release from guinea-pig myenteric plexus.
    Author: Kilbinger H, Wolf D.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1994 May; 349(5):543-5. PubMed ID: 7520537.
    Abstract:
    The effects of nitric oxide (NO) synthase inhibitors on the electrically evoked release of [3H]acetylcholine were studied in guinea-pig myenteric plexus preparations preincubated with [3H]choline. NG-monomethyl-L-arginine (EC50 5.3 mumol l-1) and NG-nitro-L-arginine (EC50 1.3 mumol l-1) concentration-dependently increased the evoked release of [3H]acetylcholine without affecting the basal outflow. The facilitatory effect of NG-mono-methyl-L-arginine was prevented by L-arginine but not by D-arginine. The results suggest that endogenous NO inhibits the depolarisation-evoked release of acetylcholine.
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