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  • Title: Alteration in the antigenic structure of M1 protein of influenza A virus mutant resistant to a new antiviral compound mopyridone.
    Author: Galabov AS, Khristova ML, Uzunov S, Wassilewa L, Bucher DJ, Kharitonenkov IG.
    Journal: Acta Virol; 1994 Feb; 38(1):5-10. PubMed ID: 7520664.
    Abstract:
    Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was found that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to the antiviral compound mopyridone as compared to the mopyridone-sensitive mutant manifested significant changes in the antigenic structure (sites 1A, 2 and 3) of M1 protein. No differences in M1 were found between rimantadine-resistant and rimantadine-sensitive mutants of influenza virus A(H3N2).
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