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  • Title: RNA polymerase: structural determinant of the chromatin loop and the chromosome.
    Author: Cook PR.
    Journal: Bioessays; 1994 Jun; 16(6):425-30. PubMed ID: 7521639.
    Abstract:
    Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.
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