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  • Title: [Effective measures against side effects by increasing ACNU dose for malignant glioma: effects on digestive organs].
    Author: Numa Y, Kasai H, Imahori T, Tsuchida T, Kawamoto K.
    Journal: Gan To Kagaku Ryoho; 1994 Sep; 21(12):2029-33. PubMed ID: 7522001.
    Abstract:
    Loading therapy consisting of the ACNU regimen was instituted as postoperative anticancer chemotherapy for malignant gliomas. The efficacy rate of the regimen was 25% at a dose of 3 mg/kg. A high incidence of hematological changes, such as leukopenia (neutropenia) and thrombocytopenia, were observed after chemotherapy. The former could be prevented by the administration of G-CSF, but platelet infusions were necessary in some patients for amelioration of thrombocytopenia. Gastroenterological symptoms, such as nausea and vomiting, were also frequently noted. Granisetron (Kytril), which is a recently developed selective competitive inhibitor of the 5-HT3 receptor, was used for the treatment of these adverse effects, and was found to be clinically effective.
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