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  • Title: [Signal-transducing ATP -- mediator of transmembranous transmission of mitogenic signals to cellular growth].
    Author: Karelin AA.
    Journal: Vestn Ross Akad Med Nauk; 1994; (6):27-34. PubMed ID: 7522697.
    Abstract:
    The paper summarizes the experimental data obtained by the author and his collective body on studies into the author's discovered cellular phenomenon--rapid living cellular plasma membranous generation and utilization of short-lived signal-transducing ATP as a transmembranous mitogenic signal-to-cellular growth transmitter by growth factor receptors associated with tyrosine kinase. It considers the conditions of the generation, cellular localization, possible mechanism of signal ATP on the plasma membrane of a living cell. It also emphasizes that there is a correlation between the generation of a short-lived signal-transducing ATP from ADP and inorganic phosphate and the oxidation of NAD.H with oxygen conjugated with proton-activated, sodium-translocating phosphorylation.
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