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  • Title: Biphenotypic M0 acute myeloid leukemia with trisomy-4.
    Author: Keung YK, Kaplan B, Douer D.
    Journal: Leuk Lymphoma; 1994 Jun; 14(1-2):181-4. PubMed ID: 7522717.
    Abstract:
    We report here a rare case of biphenotypic M0 acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.
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