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  • Title: Superoxide anion-induced histamine release from rat peritoneal mast cells.
    Author: Akagi M, Katakuse Y, Fukuishi N, Kan T, Akagi R.
    Journal: Biol Pharm Bull; 1994 May; 17(5):732-4. PubMed ID: 7522732.
    Abstract:
    We investigated the properties of superoxide anion (O2-)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO2). KO2 elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO2-induced release was temperature- and energy-dependent. KO2 rapidly increased the intracellular free Ca2+ concentration, accompanied by a marked increase of Ca(2+)-uptake. These findings indicate that the increase in intracellular Ca2+ concentration is involved in the initiation of KO2-induced histamine release, and KO2 could be used as an agent of O2(-)-induced biological reactions.
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