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  • Title: [Twenty-eight-day repeated dose toxicity test of Ajicoat SPG and Bionole in Wistar rat].
    Author: Suzuki S, Ogawa Y, Hirose A, Uchida O, Saito M, Kaneko T, Kurokawa Y.
    Journal: Eisei Shikenjo Hokoku; 1993; (111):25-33. PubMed ID: 7522736.
    Abstract:
    A twenty-eight-day repeated dose toxicity test of Ajicoat at dose levels of 0, 0.05, 0.2 or 1.0% and Bionole at dose levels of 0.2, 1.0, or 5.0% in the feed was carried out in male and female Wistar rats. Three groups, at the dose levels of 1.0% of Ajicoat, 5.0% of Bionole and control groups, were used for investigation of recovery. No animals died during the administration period. There were no significant differences in body weight gain, food consumption and organ weight between the treated and control groups. No specific changes were observed in any parameters of hematological investigations. At doses higher than 1.0% of Ajicost and Bionole groups, a significant increase of BUN value in serum was observed in both sexes. The serum glucose value increased and NEFA value decreased in male at a dose of 1.0% of Ajicoat group. These changes observed at the end of the administration period were no longer detected after the recovery period, suggesting that these effects were reversible. On histopathological examination, no specific changes were observed in the Ajicoat and Bionole treated rats. Based on these results, the no-observed-effect level was 0.2% (174 mg/kg) for both Ajicoat and Bionole.
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