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  • Title: [The mechanisms of the changes in coronary vascular resistance in anaphylactic shock].
    Author: Moĭbenko AA, Grabovskiĭ LA, Kotsiuruba VN, Bulakh VN, Tumanovskaia LV, Azarov VI, Butovich IA.
    Journal: Fiziol Zh Im I M Sechenova; 1994 Feb; 80(2):77-82. PubMed ID: 7522789.
    Abstract:
    Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.
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