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  • Title: Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat.
    Author: Moia LJ, Matsui H, de Barros GA, Tomizawa K, Miyamoto K, Kuwata Y, Tokuda M, Itano T, Hatase O.
    Journal: Brain Res; 1994 Jun 20; 648(2):337-41. PubMed ID: 7522929.
    Abstract:
    Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphocytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.
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