These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: On the origin of the genetic code.
    Author: Kuhn H, Waser J.
    Journal: FEBS Lett; 1994 Oct 03; 352(3):259-64. PubMed ID: 7523187.
    Abstract:
    A series of stages in the evolution of the genetic code is postulated, representing a chain of logical steps that leads to the present-day code. The stages described are based on translation machinery between the RNA world and that of amino acids, a model that consists of an RNA assembler strand along which RNA hairpin molecules are lined up, forming a picket-fence-like aggregate. Each hairpin carries an amino acid at the bottom of one of its legs, and the mutual proximity of amino acids achieved in this way facilitates their linkage into oligopeptides, in a sequence governed by the nucleotide sequence along the assembler strand, the code. The order in which amino acids are introduced into the code is in the approximate order of their availability, tempered by polarity and structural considerations.
    [Abstract] [Full Text] [Related] [New Search]