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  • Title: Induction of chromosomal aberrations with benzon nuclease in Chinese hamster ovary (CHO) cells.
    Author: Johannes C, Obe G.
    Journal: Mutat Res; 1994 Nov; 325(2-3):113-6. PubMed ID: 7523930.
    Abstract:
    Benzon nuclease, an endonuclease originating from Serratia marcescens, was tested for its chromosome breaking activity in Chinese hamster ovary cells. Using a permeabilizing method with hypertonic glycerol, benzon nuclease induced chromosomal aberrations in an S-phase independent manner. The frequencies of polycentric chromosomes were correlated with the dose of the enzyme and the intercellular distribution of aberrations was overdispersed.
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