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  • Title: The apocrine carcinoma of the breast. A cytological, immunohistochemical and ultrastructural study of 6 cases.
    Author: Alexiev B, Boschnakova Z, Prokopanov C.
    Journal: Zentralbl Pathol; 1994 Jul; 140(2):129-34. PubMed ID: 7524651.
    Abstract:
    The apocrine carcinoma is a rare type of invasive breast carcinomas. Characteristic features of this neoplasm are shown by the eosinophilic granular cytoplasm with apical snouts and strong expression of GCDFP-15. A review of 2000 available primary breast carcinomas identified 6 examples (0.3%) based on the definition. Architecturally, these tumors displayed either a solid-tubular or a papillary growth pattern, while cytologically the lesions were composed of large columnar epithelial cells with marked anisonucleosis and numerous PAS-positive diastase-resistant cytoplasmic granules. Immunohistochemically, apocrine breast carcinomas showed abundant GCDFP-15, CEA an c-erbB-2 oncoprotein. Electron microscopic analysis revealed the presence of numerous secretory granules. The differential diagnostic problems of apocrine breast carcinomas and malignant tumors mimicking them are discussed.
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