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  • Title: Nucleolar organizer regions in follicular tumors of the thyroid.
    Author: Shem-Tov Y, Straus M, Talmi YP, Rath-Wolfsom L, Zohar Y, Gal R.
    Journal: Head Neck; 1994; 16(5):420-3. PubMed ID: 7525511.
    Abstract:
    BACKGROUND: Nucleolar organizer regions (NORs) are loops of ribosomal DNA that occur in nucleoli and that transcribe to ribosomal RNA. NORs have been identified by means of the Ag-NOR technique in routinely processed tissues, and were found to be of discriminative value between some types of benign and malignant lesions. METHODS: Follicular lesions of the thyroid (17 adenomas and 25 carcinomas) were examined. Ten normal thyroids served as the control group. All slides were stained by the Ag-NOR technique and the number of Ag-NOR dots were counted in 50 randomly selected cells. The mean number of Ag-NORs was calculated for each case. Data were statistically analyzed by the Student's unpaired t test. RESULTS: The mean Ag-NOR counts were statistically higher in follicular carcinomas as compared to either follicular adenomas or the normal thyroid. Higher Ag-NOR counts were found in the more aggressively behaving tumors. CONCLUSIONS: It is suggested that the Ag-NOR technique could be of use as an adjunct to diagnostic histopathology and as an indicator of biologic behavior in follicular tumors of the thyroid.
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