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  • Title: Role of TCR zeta chain in T cell development and selection.
    Author: Shores EW, Huang K, Tran T, Lee E, Grinberg A, Love PE.
    Journal: Science; 1994 Nov 11; 266(5187):1047-50. PubMed ID: 7526464.
    Abstract:
    Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.
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