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  • Title: Studies on antidepressant action of a new oxazolidinone derivative AS-8.
    Author: Kostowski W, Płaźnik A, Bidziński A, Rosnowska E, Jessa M, Nazar M.
    Journal: Pol J Pharmacol; 1994; 46(1-2):15-20. PubMed ID: 7526934.
    Abstract:
    On the basis of previous laboratory studies AS-8 was suggested to possess antidepressant-like activity. Forced swim test, learned helplessness and conflict Vogel's test were performed after three prior administrations of AS-8 (24, 5 and 1 h before the test). The data have shown that AS-8 produces moderate antidepressant effect but did not induce anxiolytic-like action. Biochemical data revealed increased brain 5-HT and 5-HIAA levels following AS-8 administration. The combined treatment of rats with AS-8 (100 mg/kg) and amitriptyline (5 mg/kg) or desipramine (1.25 mg/kg) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drug given separately. The present data suggest the potential antidepressant efficacy of AS-8 in conjunction with small doses of tricyclic antidepressants.
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