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  • Title: [Inclusion of labeled precursors of macromolecular compounds in the mycobacterial cells in the presence of DP-2 preparation].
    Author: Dermicheva SG, Dosanov KSh, Koronelli TV.
    Journal: Probl Tuberk; 1993; (3):4-7. PubMed ID: 7527149.
    Abstract:
    The changes in the inclusion of 3H-phenylalanine, methyl-3H-thymidine, [2-14C]-thymidine and [5-3H]-uridine in the cells of pathogenic M. bovis-8, opportunistic M. fortuitum and saprophitic M. phlei, M. B-5 were comparatively investigated in introduction of 0.01 and 0.10% concentrations of the drug DP-2. It is shown that 0.10% DP-2 completely stops the radionuclides supply to the cells. It is suggested that the target of the drug may exist in the sphere of amino acid biosynthesis. The presence of DP-2 is capable of disturbing transport of substances to the cells.
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