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  • Title: New modified substrates for discriminating between human DNA polymerases alpha and epsilon.
    Author: Jasko MV, Semizarov DG, Victorova LS, Mozzherin DJu, Krayevsky AA, Kukhanova MK.
    Journal: FEBS Lett; 1995 Jan 02; 357(1):23-6. PubMed ID: 7528146.
    Abstract:
    Two 2'-deoxynucleoside 5'-alpha-methylenephosphonyl-beta, gamma-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase alpha from human placenta. Meanwhile, they were not recognized by DNA polymerase epsilon and beta of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus.
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