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  • Title: Synuclein proteins and Alzheimer's disease.
    Author: Brookes AJ, St Clair D.
    Journal: Trends Neurosci; 1994 Oct; 17(10):404-5. PubMed ID: 7530877.
    Abstract:
    In Alzheimer's disease, synuclein/NAC (non-amyloid beta component of Alzheimer's disease amyloid) proteins are found in presynaptic cholinergic nerve terminals that degenerate early in Alzheimer's disease, and they are also found closely linked to beta-amyloid fibrils in senile plaques. Synuclein/NAC proteins provide a potential molecular link between the degeneration of cholinergic nerve terminals, and the formation of plaques, and might have a primary role in their development.
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