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  • Title: Oral immunization against diphtheria and tetanus infections by fluid diphtheria and tetanus toxoids.
    Author: Mirchamsy H, Hamedi M, Fateh G, Sassani A.
    Journal: Vaccine; 1994 Oct; 12(13):1167-72. PubMed ID: 7530887.
    Abstract:
    Purified diphtheria toxoid incorporated in egg yolk and mixed with a medicinal plant seed was used to orally immunize rabbits against diphtheria infection. Animals were partially immunized against a lethal diphtheria toxin challenge. The immunity was complete when gastric enzyme juices were inhibited before oral vaccination by aprotinin, a natural protease inhibitor. Rabbits and monkeys were orally immunized against both diphtheria and tetanus in the same way by pre-treatment with aprotinin. Adult volunteers receiving protease inhibitor before administration of oral toxoids have shown a significant rise in specific circulating antitoxins.
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