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  • Title: [Solitary nodular calcinosis of the skin with clinical and histological particularities. About two cases (author's transl)].
    Author: Kanitakis C, Tsoïtis G.
    Journal: Ann Dermatol Venereol; 1978 Dec; 105(12):1033-40. PubMed ID: 753116.
    Abstract:
    We report 2 exceptional cases of solitary nodular calcinosis of the skin, the first to be observed in Greece, with the clinical appearance of cutaneous horn and milium respectively. The latter clinical form has not been described in the literature. Histopathological examination of the first case shows the presence of numerous calcified concretions in the papillary dermis, directly beneath the epidermis, which is intensely hyperkeratotic and papillomatous. The calcified concretions are also seen in the lymphatic capillaries, the intraepidermal sweat ducts and horny layer; at a site they perforate the epidermis and penetrate in a sweat pore. The stroma presents an angiomatous appearance. Histopathological examination of the second case shows the presence of two well demarcated calcified masses in the upper dermis, the larger one being subepidermal, the other one being situated a little further from the epidermis. The smaller mass contains numerous hair shafts and is partially surrounded by a true epithelial wall, similar to that of an epidermal cyst.
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