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  • Title: Effects of organochlorine pesticides on 36Cl- flux in primary neuronal cultures.
    Author: Pomés A, Rodríguez-Farré E, Suñol C.
    Journal: Neurotoxicology; 1994; 15(3):745-9. PubMed ID: 7531828.
    Abstract:
    Primary cultures from cortical neuronal cells were used to study the effect of organochlorine pesticides on GABA-dependent Cl- fluxes. In this system cyclodienes inhibited GABA-induced 36Cl- uptake with similar potencies to those described using brain synaptoneurosomes whereas lindane showed greater potency than that described using other in vitro systems. Basal Cl- uptake was not affected by these compounds although alpha-endosulfan exhibited a small inhibition. DDT, which mechanism of neurotoxic action has been postulated through activation of Na+ channels, did not inhibit GABA-induced 36Cl- uptake. These results clearly demonstrate that the stimulant neurotoxic effects of cyclodienes and lindane are produced by their interaction with the Cl- channel coupled to the GABAA receptor. Furthermore, these results show the usefulness of cortical neuronal cultures to study the effects of toxic agents on GABAA receptor.
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