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  • Title: [Inhibitory effect of SP on GABA-activated currents in freshly isolated rat DRG neurons].
    Author: Wu XP, Li ZW, Fan YZ.
    Journal: Sheng Li Xue Bao; 1994 Dec; 46(6):586-90. PubMed ID: 7533331.
    Abstract:
    The whole-cell patch-clamp technique was used to record GABA-activated currents in freshly isolated DRG neurons. It was found that application of SP (10(-7)-10(-5) mol/L) could induce concentration dependent inward currents in some cells (4/26), while no such current was detectable in the other neurons. However, preapplication of SP could inhibit the inward currents mediated by GABAA receptor (18/22). The inhibitory effect of SP was concentration dependent and reversible, and the desensitization of GABA-activated current could also be enhanced by SP.
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