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  • Title: Effect of lindane on galactose and leucine transport in chicken enterocytes.
    Author: Moreno MJ, Pellicer S, Marti A, Arenas JC, Fernández-Otero MP.
    Journal: Comp Biochem Physiol C Pharmacol Toxicol Endocrinol; 1994 Oct; 109(2):159-66. PubMed ID: 7533627.
    Abstract:
    Lindane (gamma-hexachlorocyclohexane) influence on the in vitro intestinal transport of D-galactose and L-leucine has been studied in isolated chicken enterocytes. Animals were injected i.p. with 30 mg/kg b.w. of the pesticide over 7 days. Total uptake of D-galactose and L-leucine was significantly decreased by lindane action. There was no alteration in the non-mediated component, but the mediated transport was markedly inhibited in both cases. Furthermore, the exit of D-galactose across the basolateral membrane, as well as (Na(+)-K+)-ATPase activity, was significantly decreased in pesticide-treated chickens.
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