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  • Title: Induction of calcium-independent nitric oxide synthase activity in cultured cerebellar granule neurons.
    Author: Sato I, Kim Y, Himi T, Murota S.
    Journal: Neurosci Lett; 1995 Jan 23; 184(2):145-8. PubMed ID: 7536905.
    Abstract:
    Cultured cerebellar granule neurons were assayed for nitric oxide synthase (NOS) activity by measuring the conversion of L-arginine to L-citrulline. Granule neurons expressed constitutive NOS activity which was calcium-dependent. Treatment of neuron cultures for 24 h with the combined stimulation of IFN-gamma plus IL-1 beta, TNF-alpha and LPS induced NOS activity by 87-fold which was calcium-independent. We conclude that cultured cerebellar granule neurons can express both the constitutive and inducible forms of NOS activity.
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