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  • Title: [Lipophilic derivatives of caffeic acid as lipoxygenase inhibitors with antioxidant properties].
    Author: Mirzoeva OK, Sud'ina GF, Pushkareva MA, Korshunova GA, Sumbatian NV, Varfolomeev SD.
    Journal: Bioorg Khim; 1995 Feb; 21(2):143-51. PubMed ID: 7538294.
    Abstract:
    We have prepared two lipophilic derivatives of caffeic acid at the carboxylic function--caffeic acid phenethyl ester, an active component of propolis, and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea. Both substances inhibit barley 5-lipoxygenase and soybean 15-lipoxygenase at micromolar concentrations. The inhibition is uncompetitive, dose-dependent and reversible. The caffeic acid derivatives also exhibit antioxidant properties and at a concentration 5-10 microM completely block the production of the reactive oxygen species in human neutrophils and in the cell-free xanthine/xanthine oxidase system.
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